Thermaltake Chaser A21 and Thermaltake S500 are both cases with the same Motherboard Compatibility (ATX, Micro ATX, Mini ITX) and Front Panel I/O (USB 2.0 Type A, USB 3.2 Gen 1 Type A). The main differences are in External 5.25" Drive Bays, Internal 2.5" Drive Bays, Internal 3.5" Drive Bays and Dimensions.
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