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Compare ASUS TUF Gaming B850-PRO WIFI7 W NEO vs M5A99FX PRO R2.0

ASUS TUF Gaming B850-PRO WIFI7 W NEO and ASUS M5A99FX PRO R2.0 are both motherboards with the same Form factor (ATX), RAM Slots (4) and Onboard USB 2.0 (3). The main differences are in Socket, Chipset, Supported Memory and Audio Chipset.
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Pangoly Score (How do we rate?)
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Pangoly Score (How do we rate?)
86
Brand
ASUS
Brand
ASUS
Model
  • TUF GAMING B850-PRO WIFI7 W NEO
  • 90MB1NW0-M0EAY0
  • 90MB1NW0-M0VAY0
Model
  • M5A99FX PRO R2.0
  • M5A99FX-PRO-R2
Release Date
📅 January 2026
Release Date
📅 December 2012
* First availability for purchase, it may not correspond to the actual market launch date.
User reviews
User reviews
★★★★★
(465 reviews)
Price history
View Details ►
Price history
View Details ►
Compatible PC parts
Compatible PC parts
Pros
-
Pros
  • Overclocking features
  • Supports NVIDIA Quad-GPU SLI
  • Supports AMD Quad-GPU CrossFireX
Series
-
Series
Socket
AM5
Socket
AM3+
Form factor
ATX
Form factor
ATX
Chipset
AMD B850
Chipset
AMD 990FX
Supported Memory
DDR5
4800Mhz 5000Mhz 5200Mhz 5600Mhz 5800Mhz 6000Mhz 6200Mhz 6400Mhz 6600Mhz 6800Mhz 7000Mhz 7200Mhz 7600Mhz 7800Mhz 8000Mhz
Supported Memory
DDR3
1066Mhz 1333Mhz 1600Mhz 1866Mhz 2133Mhz
* High clock speeds may require enabling the XMP profile in the motherboard BIOS
** RAM support may also depend on the CPU memory controller
ECC RAM Support
No
ECC RAM Support
No
Audio Chipset
Realtek ALC1220P 7.1 Surround Sound High Definition Audio CODEC*
- Impedance sense for front and rear headphone outputs
- Internal audio Amplifier to enhance the highest quality sound for headphone and speakers
- Supports: Jack-detection, Multi-streaming, Front Panel Jack-retasking
- High quality 120 dB SNR stereo playback output and 113 dB SNR recording input (Line-in)
- Supports up to 32-Bit/192 kHz playback**
Audio Features
- Audio Shielding
- Premium audio capacitors
- Dedicated audio PCB layers
- Audio cover
- Unique de-pop circuit
* A chassis with an HD audio module in the front panel is required to support 7.1 Surround Sound audio output.
** Due to limitations in HDA bandwidth, 32-Bit/192 kHz is not supported for 7.1 Surround Sound audio.
Audio Chipset
Realtek ALC892
Audio Channels
7.1 Channels
Audio Channels
8 Channels
LAN Chipset
-
LAN Chipset
Realtek 8111F
Max LAN Speed
2.5Gbps
Max LAN Speed
10/100/1000Mbps
SLI Support
No
SLI Support
Yes
CrossFire Support
No
CrossFire Support
Yes
RAID Support
Yes
RAID Support
No
Back Connect
No
Back Connect
No
Back I/O Ports
  • 4 x USB 10Gbps ports (2 x Type-A + 2 x USB Type-C)
  • 4 x USB 5Gbps ports (4 x Type-A)
  • 2 x USB 2.0 ports (2 x Type-A)
  • 1 x DisplayPort
  • 1 x HDMI port
  • 1 x Wi-Fi module
  • 1 x Realtek 2.5Gb Ethernet port
  • 3 x Audio jacks
  • 1 x BIOS FlashBack button
  • 1 x Clear CMOS button
Back I/O Ports
-
Wireless LAN
Yes
Wireless LAN
No
Wi-Fi Generation
7
Wi-Fi Generation
-
PCI-Express x16 Slots
2
PCI-Express x16 Slots
4
PCI-Express x4 Slots
0
PCI-Express x4 Slots
0
PCI-Express x1 Slots
2
PCI-Express x1 Slots
1
SATA 6 Gbps Ports
4
SATA 6 Gbps Ports
7
SATA Express Ports
0
SATA Express Ports
0
M.2 Ports
3
M.2 Ports
0
M.2 Devices support
  • 2280 - M Key
  • 2280 - M Key
  • 2242 / 2260 / 2280 / 22110 - M Key
  • 2280 - M Key
M.2 Devices support
-
RAM Slots
4
RAM Slots
4
Maximum Supported RAM
256 GB
Maximum Supported RAM
32 GB
Onboard USB 2.0
3
Onboard USB 2.0
3
Onboard USB 3.2 Gen 1
1
Onboard USB 3.2 Gen 1
1
Onboard USB 3.2 Gen 2
0
Onboard USB 3.2 Gen 2
0
Onboard USB 3.2 Gen 2x2
1
Onboard USB 3.2 Gen 2x2
0

Comparison and key differences summary

⛔ You are comparing motherboards with different sockets. They cannot support the same CPUs. Try to compare motherboards within the same platform.

Reasons to buy the ASUS TUF Gaming B850-PRO WIFI7 W NEO:

  • Newer Product, it was released around 13 years later
  • Supports RAID
  • Wireless LAN Integrated
  • +1 Slots PCI-E x1
  • +3 Ports M.2
  • +224 GB maximum RAM supported

Buy now

Reasons to buy the ASUS M5A99FX PRO R2.0:

  • 28% cheaper, you can save $67.99
  • Supports NVIDIA SLI
  • Supports AMD CrossFire
  • +2 Slots PCI-E x16
  • +3 Ports SATA 6Gb/s

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